Please take note of this setup key as it will be needed during product installation." The download bits are included in Visual Studio Team Agents 2010, which is additional software made available with Visual Studio 2010 Ultimate and other Visual Studio 2010 products. For products acquired through physical fulfillment, the setup key is printed on the media sleeve.įor products that are available for download from the Microsoft Volume Licensing Service Center ( VLSC ) Web site, the setup key is provided on the download screen and may be accompanied with the following text: "Some products available for download require setup keys. There are three ways to obtain setup keys: For support related to product keys and activation, call your Microsoft Activation Center. Please visit Microsoft Help and Support for a variety of product support options. When you call, you will be asked to provide Volume Licensing agreement information and proof of purchase. You can call the Activation Call Center to obtain the setup keys you need. There are two ways to obtain these setup keys:įor products that are available for download from the Microsoft Volume Licensing Service Center (VLSC ) Web site, the setup key is provided on the download screen. Server Setup keys are used to "unlock" the product. If you have not installed a trial version and/or will be installing the full version of this product, available on VLSC, no key needs to be entered. For full instructions on how to activate Visual Studio 2010 with your key, click here. Furthermore, falcipain-2 was identified to be a plausible target site of the hybrids given their antimalarial potency.If you have previously installed a trial version of Visual Studio 2010, the software can be upgraded to the full version with your Volume Licensing key, without the need to reinstall the software. Molecular docking suggested that the cytotoxicity of reported hybrids could be possibly due to their dual inhibition of α- and β-tubulins at GTP and colchicine binding sites, respectively. Interestingly, the chalcone–coumarin 18 was the most potent antimalarial compound affording IC 50 value of 1.60 μM. Significantly, the high cytotoxic potency of the hybrid 11 was shown to be non-toxic to normal cells. Analogs ( 10, 11, 16 and 18) exhibited higher inhibitory efficacy than the control drug, etoposide, in HepG2 cells. Most of the synthesized hybrids, except for analogs 10 and 16, displayed cytotoxicity against MOLT-3 cell line without affecting normal cells. Hybrid molecules were evaluated for their cytotoxic activity against four cancer cell lines (e.g., HuCCA-1, HepG2, A549 and MOLT-3) and antimalarial activity toward Plasmodium falciparum. A new series of chalcone–coumarin derivatives ( 9– 19) linked by the 1,2,3-triazole ring were synthesized through the azide/alkyne dipolar cycloaddition.
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